Search results for " scrapie."

showing 3 items of 3 documents

Prion protein gene frequencies in three Sicilian dairy sheep populations

2008

The objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks, in which the animals were crossbreds derived from indigenous Sicilian dairy breeds. PrP genotypes are described for the three codons 136 (Alanine or Valine; A, V), 154 (Histidine or Arginine; H, R), and 171 (Glutamine, Arginine or Histidine; Q, R, H) which represent polymorphisms known to be linked with scrapie susceptibility. The Valle del Belice haplotype frequencies were 32.3% ARR, 6.5% AHQ,…

GeneticsPrPsheep040301 veterinary sciencesHaplotype frequency Prion protein Scrapie Sheep.Haplotype0402 animal and dairy scienceOutbreakScrapie04 agricultural and veterinary sciencesBiology040201 dairy & animal science0403 veterinary scienceSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoValineGenotypeAnimal Science and ZoologyfrequencieFlocklcsh:Animal culturePrion proteinGenelcsh:SF1-1100
researchProduct

Indagini archeozoologiche della Palermo antica: la Gancia, Palazzo Bonagia e Via Imera.

L’analisi archeozoologica della Palermo medioevale qui presentata si inserisce nell’ambito degli studi di antropologia e di archeologia medievale che da oltre un decennio stanno interessando il centro storico della città. Il presente studio mira alla ricostruzione dell’ecologia umana durante il periodo di islamizzazione della Sicilia e di Palermo, attraverso l’analisi dei resti faunistici di tre siti inediti del centro storico di Palermo, la Gancia, Palazzo Bonagia e Via Imera, in un periodo compreso tra la fine del IX e il X sec. d.C., e l’analisi comparativa di resti provenienti da centri rurali siciliani, alcuni di questi databili fino al XV secolo. L’analisi ha messo in evidenza alcuni …

Islamism faunal remains Taphonomy Paleoenvironment Paleoeconomy Ovis ScrapieSettore BIO/08 - AntropologiaIslamismo resti faunistici tafonomia paleoambiente paleoeconomia Ovis scrapie.
researchProduct

Mathematical models for the diffusion magnetic resonance signal abnormality in patients with prion diseases

2014

In clinical practice signal hyperintensity in the cortex and/or in the striatum on magnetic resonance (MR) diffusion-weighted images (DWIs) is a marker of sporadic Creutzfeldt–Jakob Disease (sCJD). MR diagnostic accuracy is greater than 90%, but the biophysical mechanisms underpinning the signal abnormality are unknown. The aim of this prospective study is to combine an advanced DWI protocol with new mathematical models of the microstructural changes occurring in prion disease patients to investigate the cause of MR signal alterations. This underpins the later development of more sensitive and specific image-based biomarkers. DWI data with a wide a range of echo times and diffusion weightin…

MalePathologysCJD sporadic Creutzfeldt–Jakob diseaseROI region of interestPrion diseasePrPSc prion protein scrapieElectroencephalographyFOV field of viewlcsh:RC346-429Prion DiseasesADC apparent diffusion coefficientTI inversion timeRPE rapidly progressive encephalopathyAged 80 and overTE echo timeBrain Mappingmedicine.diagnostic_testBrainRegular ArticleMiddle AgedBIC Bayesian information criterionTR repetition timemedicine.anatomical_structureNeurologylcsh:R858-859.7FemaleMPRAGE magnetization-prepared rapid acquisition gradient-echoAbnormalitySS-SE single shot spin-echoAdultmedicine.medical_specialtyCognitive NeuroscienceCreutzfeldt–Jakob diseaseCNR contrast to noise ratioEPI echo-planar imagingNeuropathologyPrPC prion protein cellularGrey matterSpongiform degenerationlcsh:Computer applications to medicine. Medical informaticsEEG electroencephalogramDiffusion MRINeuroimagingImage Interpretation Computer-AssistedmedicineHumansRadiology Nuclear Medicine and imaginglcsh:Neurology. Diseases of the nervous systemAgedCJD Creutzfeldt–Jakob diseaseGSS Gerstmann–Sträussler–Scheinker syndromebusiness.industryDWI diffusion weighted imagingDiffusion MRI; Biophysical models; Creutzfeldt-Jakob disease; Prion disease; Spongiform degenerationMagnetic resonance imagingModels TheoreticalHyperintensityCreutzfeldt-Jakob diseaseDiffusion Magnetic Resonance ImagingNeurology (clinical)businessBiophysical modelsDiffusion MRINeuroImage: Clinical
researchProduct